Medical network on April 13 - hyaluronic acid (aka "hyaluronic acid" or "hyaluronic acid") is a kind of natural exists in biological polysaccharide (including human) of polymer material in the body. In recent 10 years, as the main raw material of the beauty industry, hyaluronic acid in the international market boom, cause the extensive concern of the medical professionals. 

 

American manufacturers in the early 1960 s, which is extracted from the poultry slaughterhouses of scraps from the rooster comb medicinal grade hyaluronic acid, was mainly used as adhesive agent in eye surgery. Due to low levels of hyaluronic acid in a comb and purification process is very complex, the medicinal grade hyaluronic acid per kilogram in the international market that cost up to $10000 to $20000. 

 

To the end of the 1970 s, the global pharmaceutical grade hyaluronic acid production but only hundreds of kilograms. In the early 1980 s, Japanese companies such as Chinese and foreign pharmaceutical co., LTD takes the lead in using microorganism fermentation to produce hyaluronic acid to be successful, since then started hyaluronic acid industry in the new world, the market prices also fell back quickly. 

 

According to foreign media reports, the four major pharmaceutical application fields of hyaluronic acid as follows: 1. The treatment/alleviate osteoarthritis; 2. As antiblocking agents in eye surgery; 3. The dermal filler (the beauty industry's largest purposes); 4. Bladder ureter defence of the flow. Reportedly, hyaluronic acid and some new USES, such as anti-tumor, treatment of dry eyes and skin anti-wrinkle agents, etc. 

 

New USES for promoting market growth 

 

With large tonnage production technology promotion and unit fermentor level enhances unceasingly, global production is rising fast, hyaluronic acid for hyaluronic acid market development laid a solid foundation. According to foreign media reports, in the mid - 1990 - s, the world medical hyaluronic acid market scale in roughly $420 million to $550 million. But 2010 years later, the global market has crossed $10 billion total sales hyaluronic acid, Denmark, the United States and Japan to become the world's three big producer and exporter of hyaluronic acid. 

 

Why international hyaluronic acid market will appear after 2010 explosion? According to western medical media analysis, is the most important factor, hyaluronic acid, as a kind of non-toxic harmless physical materials found new USES in the beauty/cosmetic industry. According to European cosmetic industry association statistics, in 2012 the global cosmetic industry output value as high as $16.8 billion, hyaluronic acid contributed 60% ~ 70%. Hyaluronic acid has become an indispensable raw material beauty and cosmetic industry. 

 

Promoting international market growth of another factor hyaluronic acid is a menacing "silver hair tide". The elderly are susceptible to degenerative joint disease and senile cataract, the treatment of these two diseases are needed to hyaluronic acid. German oculist first found in 1993, for patients with degenerative joint disease old man knee joint cavity injection of hyaluronic acid, can relieve the symptoms of pain, and restore its ability to walk. This new discovery published in the international journal of orthopaedics, drawn wide attention of the doctor, after injection of hyaluronic acid doctor became the various countries' universal way for the treatment of joint pain. According to foreign reports, in recent years, the levels of hyaluronic acid injection with geometric progression growth, annual sales are mostly used in the treatment of senile degenerative joint disease. 

 

Natural extract product price is high 

 

At present, the international market and hyaluronic acid, there are mainly two kinds of API production way, namely, natural raw materials (such as comb or pig eyes) extraction and microorganism fermentation. It is reported that the United States still insist on using the comb medicinal grade hyaluronic acid, extract production products not only for the use of domestic medicine, also exports to Canada and Mexico and other neighboring countries. Microorganism fermentation mainly to Japan, France, Italy, Denmark and China and other countries of the hyaluronic acid has been adopted by the manufacturer. 

 

According to foreign reports, the extraction and fermentation production of natural hyaluronic acid production for 8 (%), but due to different production technology and quality standards, natural extract hyaluronic acid for fermentation to produce a few times of hyaluronic acid. To 2015, the global natural hyaluronic acid and combined fermentation production of hyaluronic acid production has exceeded 300 tons mark (foreign news that last year's global hyaluronic acid production has close to 400 tons), mainly comes from the international beauty industry the huge demand for hyaluronic acid. According to foreign media reports, the global hyaluronic acid industry in 2020 to the compound growth rate will remain at 9.2% ~ 9.5%, this belongs to great growth in the pharmaceutical industry. 

 

Compared with western developed countries, hyaluronic acid industry in China started relatively late. Until the 1980 s, China's coastal provinces such as jiangsu only biochemical pharmaceutical use comb as raw material, a small amount of production of hyaluronic acid (estimates of hyaluronic acid production in the country but a decade or two kilograms), the quality is not the medicinal grade hyaluronic acid standards of developed countries. 

 

In the 1980 s, China's pharmaceutical enterprises began experimenting with hyaluronic acid production by microorganism fermentation and success, since domestic hyaluronic acid products official enter the market at home and abroad. Is understood to have received hyaluronic acid production, domestic manufacturer of five, namely Shanghai HaoHai biotechnology company, Shanghai hundred plus one (now renamed as Shanghai Victoria towers pharmaceutical) pharmaceutical company, shandong big freedia, dongying, shandong province, the company and hangzhou xiehe medical equipment company, etc. 

 

Learned, and a decade or two domestic mses hyaluronic acid production by fermentation product, but the company's products are food grade hyaluronic acid, the price is less than 10% of medicinal grade hyaluronic acid. Comprehensive various sources, at present, China's total output of hyaluronic acid can have up to 200 ~ 250 tons, including medicinal grade/cosmetic grade hyaluronic acid production is around one hundred tons, our export of hyaluronic acid accounted for about 52% of the total hyaluronic acid production in China.