The drug has been approved by the FDA for the past 30 years, and the FDA has approved 67 treatments. With the development of technology and the rapid development of the basic research on immunology, the design of antibody drug is becoming more and more varied and the application scope is gradually expanded. Let's take a look at some of the "best drug". 

 

The most expensive 

 

The name Soliris, which is the most famous brand of clothing, was developed by the company of alex, which costs us $540,000 per year. The second is a dual-specific antibody called Blincyto and pd-lavencio, which costs $180,000 per person. In addition, pd-1 antibody Opdivo, Keytruda, pd-l1 antibody Tecentriq, VEGFR2 antibody Cyramza's drug cost was $140,000 to $150,000 a year. 

 

Best selling 

 

The company's Humira has been the world's king of medicine for the fifth year in a row, with sales of $160.78 billion in 2016, the equivalent of the company's market value. 

 

Give the drug the lowest frequency 

 

The CD20 antibody Ocrevus is used to treat multiple sclerosis with a frequency of 6 months. It's not because the antibody is longer than normal half-life, but due to its mechanism of action is to clear B cells, B cells after a few months after the treatment will reply to a certain level. 

 

In addition, the RANKL antibody Prolia was used to treat osteoporosis and the frequency of medication was also 6 months. It is also due to the effect of preventing bone loss and the balance of the broken bone cells in the long period. Xgeva, which has the same active component (dinosema), used to treat bone transfer, was given a frequency of four on Monday. 

 

4, give the medicine the highest frequency 

 

The bispecific antibody, Blincyto, is a SCFV structure, with no long-term effects of Fc and only 2h in the half-life, so the drug needs to be injected every day in a continuous vein. 

 

In addition, Lucentis is the structure of the Fab, the plasma half-life is also very short, but because it is an ophthalmic drug, it is injected through vitreous and the half-life of the glass is nine days. 

 

The dosage is maximal 

 

The dosage of an antibody drug is usually a few hundred milligrams, which is used to treat the slow drench of the CD20 antibody Arzerra, which dose up to 2000mg/d. 

 

In addition, the pd-l1 antibody Tecentriq and C5 monosolids were given 1200mg/times. 

 

Strictly speaking, Praxbind is the most dosing drug, 5g. 

 

The dosage is minimal 

 

The two-specific antibody, Blincyto, has a dose of 28ug per day, but needs to be given daily. The dose of Lucentis in the eye is 0.3, 0.5 mg. 

 

The indications are the most 

 

Who Humira worldwide, the number of approved indications are 14, many new indications including orphan drug, expand, pediatric indications for Humira bring longer exclusive periods in the market segment. 

 

The highest approval 

 

On March 4, 2015, the F.D.A. decided to approve the pd-1 antibody Opdivo, which is owned by bristol-myers squibb for four working days, to treat non-small-cell lung cancer (new indications). 

 

First use priority review vouchers 

 

Novartis first get a priority review vouchers, but also not too will use at the time, in 2011 for the supplement of Ilaris treatment of gouty arthritis, but was refused, priority review vouchers used to fail. The first antibody that successfully used the first review voucher was sanofi's PCSK9 antibody, Praluent, which successfully made the detour and became the first PCSK9 antibody to go public. The PCSK9, however, is a must-have for the giants, with the presence of a strong position in the patent on the table, putting sanofi in an awkward position. 

 

10, the earliest constructs 

 

Dali's monoclonal antibodies were first developed by roche to suppress immune rejection of kidney transplants, known as Zenapax, which was launched in 1997. Best health/wiki ahab in Dali bead from the optimization design of single, expression vector, glycosylation modification are modified, and get high yield technology Dali bead sheet resistance, in 2016 the FDA approved, for the treatment of multiple sclerosis, called Zinbryta goods. 

 

The most "dragon" 

 

Praxbind's reversal of the dabiegin is mainly intended to ensure the safety of the drugs in the anticoagulant.